— 藥理與非經腸給藥 · EASY · MCQ —
病人正接受華法林(Warfarin)治療。護理師應監測哪項實驗室檢查以評估此藥物的治療效果?
A client is prescribed warfarin therapy. Which laboratory test should the nurse monitor to evaluate the effectiveness of this medication?
- AProthrombin Time (PT) / INR✓ 正解凝血酶原時間 (PT) / 國際標準化比值 (INR)
- BPlatelet count血小板計數
- CHemoglobin and Hematocrit血紅素和血球容積比
- DActivated Partial Thromboplastin Time (aPTT)活化部分凝血活酶時間 (aPTT)
— Explanation · 中文詳解 —
Warfarin 作用於維生素 K 依賴性凝血因子,臨床上透過 PT/INR 來監測其抗凝血效能。aPTT 是用來監測肝素(Heparin)的效果。血小板與血紅素數值與 Warfarin 的直接療效評估無直接關聯。
Warfarin inhibits vitamin K-dependent clotting factors, so its therapeutic effect is monitored using the Prothrombin Time (PT) and International Normalized Ratio (INR). The activated Partial Thromboplastin Time (aPTT) is used to monitor heparin therapy, while platelet counts and hemoglobin levels do not directly assess warfarin efficacy.
✦ 台美臨床差異
台美皆以 INR 作為黃金標準,美國基層醫療常設有抗凝血門診(Coumadin Clinic),台灣多由血液腫瘤科或心臟科醫師監控。