病人獲開立 Alendronate 以治療骨質疏鬆。最重要的衛教重點是什麼？
A client is prescribed alendronate for osteoporosis. What is the most important teaching point?
- ATake it before bedtime to improve absorption睡前服用以促進吸收
- BCrush the tablet for easier swallowing將藥片壓碎以便吞嚥
- CTake the medication with a full meal隨正餐服用藥物
- DRemain upright for 30 minutes after taking the medication✓ 正解服用藥物後保持直立姿勢 30 分鐘
Alendronate 屬於雙磷酸鹽類（Bisphosphonates）藥物，主要用於治療骨質疏鬆。此類藥物具有極強的食道刺激性，若藥物未順利進入胃部或發生逆流，極易造成嚴重的食道炎、食道潰瘍甚至穿孔。護理師必須指導個案在空腹狀態下，搭配一大杯白開水服用，且服藥後至少 30 分鐘內維持直立姿勢（站立或坐姿），以確保藥物能迅速通過食道進入胃部，防止藥物殘留造成化學性灼傷。
Alendronate is a bisphosphonate used to treat osteoporosis. This class of medication is highly irritating to the esophagus, and if the drug does not pass smoothly into the stomach or if reflux occurs, severe esophagitis, esophageal ulceration, or even perforation can result. The nurse must instruct the client to take the medication on an empty stomach with a full glass of water and to remain upright (standing or sitting) for at least 30 minutes after administration, so the medication moves rapidly through the esophagus into the stomach and does not remain in contact with the mucosa, preventing chemical burns.
在美國臨床實務中，藥師與護理師會強調藥物必須搭配「白開水」而非其他飲料，且病人若有吞嚥困難（Dysphagia）或食道狹窄病史，通常會評估是否更換藥物種類，而非僅僅進行衛教。