— 藥理與非經腸給藥 · HARD · MCQ —
一位接受靜脈輸注硫酸鎂治療子癇前症的病人，出現下列哪項發現需立即處理？
Which assessment finding in a client receiving IV magnesium sulfate for preeclampsia warrants immediate intervention?
- ASerum magnesium level of 8 mg/dL血清鎂濃度為 8 mg/dL
- BUrine output of 25 mL/hr尿量為 25 mL/hr
- CAbsence of deep tendon reflexes深腱反射消失
- DRespiratory rate of 10 breaths/min✓ 正解呼吸頻率為 10 次/分
— Explanation · 中文詳解 —
硫酸鎂（Magnesium Sulfate）常用於治療子癇前症（preeclampsia），透過抑制中樞神經系統來預防癲癇發作。然而，其治療指數狹窄，過量會導致呼吸抑制、肌腱反射消失與心臟停搏。呼吸抑制（呼吸速率 <12 次/分）是中毒的致命徵兆，必須立即停止輸注並準備解毒劑（如葡萄糖酸鈣）。尿量過少也會導致鎂離子蓄積，需密切監測，但呼吸抑制具有最高危險性。
Respiratory depression is the most critical and life-threatening sign of magnesium sulfate toxicity, requiring immediate intervention such as stopping the infusion and administering calcium gluconate. While low urine output and absent reflexes also indicate toxicity, respiratory compromise poses the greatest immediate threat to the client's airway and survival.