護理師正在審閱一位有癲癇病史且服用苯妥英鈉（phenytoin）的病人藥物清單。下列哪項潛在不良反應需要護理師立即介入？
A nurse is reviewing the medication list for a client with a history of seizures who is taking phenytoin. Which potential adverse effect requires immediate nursing intervention?
- ANystagmus眼球震顫
- BSedation嗜睡
- CGingival hyperplasia牙齦增生
- DSevere rash✓ 正解嚴重皮疹
苯妥英鈉（Phenytoin）常見副作用包括牙齦增生、輕微嗜睡或眼球震顫，但出現嚴重皮疹（severe rash）必須高度警覺，這可能是史帝文生-強森症候群（Stevens-Johnson Syndrome, SJS）或毒性表皮壞死溶解症（TEN）的早期徵兆。這類反應具致命風險，必須立即停止用藥並通知醫師，以防病情惡化。
Amphotericin B is highly nephrotoxic, potentially causing acute kidney injury and electrolyte imbalances such as hypokalemia and hypomagnesemia. Monitoring serum creatinine is the most critical action because it serves as a sensitive indicator of renal filtration function and early signs of drug-induced kidney damage. While other labs may be relevant, preserving renal function is the primary concern during this therapy.