— 藥理與非經腸給藥 · MEDIUM · MCQ —
護理師照顧一位服用華法林（Warfarin）的病人。應優先檢視哪項檢驗結果以評估藥物療效？
A nurse is caring for a client receiving warfarin. Which laboratory result should the nurse prioritize to evaluate the drug's effectiveness?
- AProthrombin Time (PT)凝血酶原時間 (PT)
- BInternational Normalized Ratio (INR)✓ 正解國際標準化比值 (INR)
- CPlatelet Count血小板計數
- DActivated Partial Thromboplastin Time (aPTT)活化部分凝血活酶時間 (aPTT)
— Explanation · 中文詳解 —
華法林是一種維生素 K 拮抗劑，臨床上採用國際標準化比率（INR）來標準化評估藥效，因為 PT 值在不同實驗室可能存在變異。INR 提供更可靠的抗凝血監測指標，而 aPTT 是用於評估肝素（Heparin）的藥效。血小板數目則是用於監測肝素誘導之血小板減少症（HIT）。
Warfarin is a vitamin K antagonist. Clinically, the International Normalized Ratio (INR) is used to standardize evaluation of its effect, because PT values may vary between laboratories. INR provides a more reliable indicator for anticoagulant monitoring, while aPTT is used to evaluate the effect of heparin. Platelet count is monitored for heparin-induced thrombocytopenia (HIT).
✦ 台美臨床差異
台美抗凝血劑藥物管理流程高度一致，皆高度依賴 PharmD 或醫師根據 INR 調整華法林劑量。