— 藥理與非經腸給藥 · EASY · MCQ —
病人正持續靜脈輸注肝素（heparin）。護理師應監測下列哪項實驗室數據以評估治療效果？
A client is receiving a continuous intravenous infusion of heparin. Which laboratory value should the nurse monitor to assess the therapeutic effect?
- AActivated partial thromboplastin time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- BProthrombin time (PT)凝血酶原時間 (PT)
- CInternational normalized ratio (INR)國際標準化比值 (INR)
- DPlatelet count血小板計數
— Explanation · 中文詳解 —
Heparin 的藥理作用在於抑制凝血酶與凝血因子，其抗凝血效果需透過 aPTT 來監測。PT/INR 是用於監測口服抗凝劑 Warfarin 的指標。血小板計數雖需監測以防肝素引起的血小板減少症（HIT），但非評估其抗凝血治療效果的直接指標。
Heparin works by inhibiting thrombin and clotting factors, and its anticoagulant effect must be monitored with aPTT. PT/INR is used to monitor the oral anticoagulant warfarin. Although platelet count should be monitored to detect heparin-induced thrombocytopenia (HIT), it is not the direct measure of the drug's therapeutic anticoagulant effect.
✦ 台美臨床差異
無顯著臨床差異，兩地皆以 aPTT 作為肝素輸注的調整基準。