護理師衛教一位病人服用 Atorvastatin 的注意事項。下列何者顯示病人已了解？（選所有適合的）
A nurse is teaching a client about taking Atorvastatin. Which statements indicate that the client understands the instructions? (Select all that apply.)
- AI will report any muscle pain or weakness to my doctor✓ 正解我會向醫師報告任何肌肉疼痛或無力
- BI should take this medication with grapefruit juice to increase absorption我應該用葡萄柚汁送服此藥物以增加吸收
- CI will have my liver enzymes checked regularly✓ 正解我會定期接受肝酵素檢查
- DI can stop taking the medication once my cholesterol levels are normal一旦我的膽固醇指數正常，我可以停止服藥
- EI should take this medication in the evening or at bedtime✓ 正解我應該在傍晚或就寢時服用此藥物
史他汀類（Statins）藥物常見副作用為橫紋肌溶解，故肌肉疼痛需警覺。肝功能監測為常規步驟。因膽固醇合成多在夜間，睡前服用效果佳。B 選項錯誤：葡萄柚汁會抑制藥物代謝，導致濃度過高產生毒性。D 選項錯誤：慢性病用藥不可擅自停藥，否則指數會反彈。
A common adverse effect of statins (e.g., atorvastatin) is rhabdomyolysis, so muscle pain or weakness warrants prompt reporting. Liver enzyme monitoring is standard. Because cholesterol synthesis is highest at night, bedtime dosing is most effective. Option B is wrong: grapefruit juice inhibits statin metabolism and increases drug levels and toxicity. Option D is wrong: statins are chronic therapy and should not be stopped abruptly, or cholesterol will rebound.
台美對 Statins 的衛教皆強調肌肉痛與肝指數，但國外較常強調葡萄柚交互作用，台灣健保對血脂追蹤頻率有明確規範。