— 藥理與非經腸給藥 · EASY · MCQ —
一位病人正接受肝素(Heparin)靜脈輸注。護理師應監測哪項檢驗值以評估治療成效?
A client is receiving an IV infusion of heparin. Which laboratory value should the nurse monitor to evaluate the effectiveness of this therapy?
- AActivated Partial Thromboplastin Time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- BPlatelet count血小板計數
- CInternational Normalized Ratio (INR)國際標準化比值 (INR)
- DProthrombin Time (PT)凝血酶原時間 (PT)
— Explanation · 中文詳解 —
肝素(Heparin)透過影響內在凝血路徑發揮作用,臨床上透過監測 aPTT 來調整劑量。通常需將 aPTT 控制在正常對照值的 1.5 到 2.5 倍之間。PT 和 INR 是用來監測 warfarin 的指標,而血小板計數則是為了預防肝素誘導之血小板低下症(HIT),並非評估肝素抗凝血效能的指標。
Heparin acts on the intrinsic coagulation pathway, so the activated partial thromboplastin time (aPTT) is the standard laboratory value used to monitor its therapeutic effectiveness. The goal is typically to maintain the aPTT at 1.5 to 2.5 times the control value, whereas PT and INR are used to monitor warfarin therapy.
✦ 台美臨床差異
美台醫療院所皆廣泛使用 aPTT 監測肝素,但部分單位已採用 anti-Xa 因子測試。