— 藥理與非經腸給藥 · EASY · MCQ —
護理師準備給予深層靜脈栓塞病史的病人華法林（Warfarin）。應評估哪項檢驗數值？
A nurse is preparing to administer warfarin to a client with a history of deep vein thrombosis. Which laboratory value should the nurse evaluate?
- AActivated Partial Thromboplastin Time (aPTT)活化部分凝血活酶時間 (aPTT)
- BHemoglobin and Hematocrit血色素與血球容積比
- CPlatelet count血小板計數
- DProthrombin Time (PT) and INR✓ 正解凝血酶原時間 (PT) 與國際標準化比值 (INR)
— Explanation · 中文詳解 —
Warfarin 透過抑制肝臟合成依賴維生素 K 的凝血因子來發揮作用，臨床上透過測量凝血酶原時間（PT）及其國際標準化比值（INR）來監測藥效。相較於肝素（Heparin）監測 aPTT，INR 是調整 Warfarin 劑量的黃金標準。
Warfarin inhibits the synthesis of vitamin K-dependent clotting factors, so its therapeutic effect is monitored using Prothrombin Time (PT) and the International Normalized Ratio (INR). The INR serves as the gold standard for adjusting warfarin dosages, unlike the aPTT which is used to monitor heparin therapy.
✦ 台美臨床差異
兩地均依循國際指引監測 INR，但在台灣，基層醫療診所對 INR 的嚴格控管與衛教比醫院體系更具挑戰性。