— 藥理與非經腸給藥 · HARD · MCQ —
護理師給予甘精胰島素（Insulin Glargine）。下列哪項描述最能正確說明此藥的藥物動力學？
A nurse is administering insulin glargine. Which statement best describes the pharmacokinetics of this medication?
- AIt should be mixed with NPH insulin to increase duration應與中效胰島素(NPH)混合以增加持續時間
- BIt has a sharp peak effect at 4 hours在4小時時有明顯的高峰效應
- CIt acts as a rapid-acting insulin for mealtime control作為速效胰島素用於餐時血糖控制
- DIt is a long-acting insulin with no defined peak✓ 正解是一種無明確高峰的長效胰島素
— Explanation · 中文詳解 —
甘精胰島素（Insulin Glargine）是一種長效型基礎胰島素（Long-acting, basal insulin）。其結構設計使其在體內緩慢釋放，提供全天候（約 24 小時）平穩的血糖控制，因此具有「無高峰（Peakless）」的藥物動力學特性。由於其酸鹼值特性，嚴禁與其他胰島素（如 NPH）混合，否則會導致藥效改變及沉澱。
Insulin glargine is a long-acting basal insulin. Its structure is designed to release slowly within the body, providing steady, around-the-clock (approximately 24 hours) glycemic control, and therefore has a 'peakless' pharmacokinetic profile. Because of its acidic pH characteristics, mixing with other insulins (such as NPH) is strictly prohibited, as this would alter drug action and cause precipitation.