— 藥理與非經腸給藥 · MEDIUM · MCQ —
病人靜脈輸注 vancomycin，出現何種現象代表發生紅人症候群？
A client is prescribed intravenous vancomycin. Which manifestation indicates the client is experiencing Red Man Syndrome?
- AGeneralized urticaria and bronchospasm全身性蕁麻疹與支氣管痙攣
- BSudden onset of fever and chills突然發作發燒與畏寒
- CEdema of the tongue and throat舌頭與喉嚨水腫
- DHypotension and flushing of the face and neck✓ 正解低血壓與面部及頸部潮紅
— Explanation · 中文詳解 —
紅人症候群（Red Man Syndrome）是由於 vancomycin 輸注過快導致組織胺大量釋放，特徵為臉部、頸部與上半身出現潮紅、低血壓及搔癢。此為類過敏反應（非 IgE 媒介），應立即減慢輸注速度或停止輸注，與真正的嚴重過敏反應（如氣管收縮、舌腫脹）不同。
Red Man Syndrome is characterized by flushing of the face and neck accompanied by hypotension, caused by rapid histamine release due to fast vancomycin infusion. This reaction is distinct from anaphylaxis, which typically presents with urticaria, bronchospasm, or angioedema.
✦ 台美臨床差異
美台皆強調輸注時間至少需一小時，但台灣部分單位對 vancomycin 的濃度規範可能較寬鬆。