— 藥理與非經腸給藥 · HARD · MCQ —
病人獲開立 Cyclosporine。哪項評估發現最令護理師擔憂？
A client is prescribed Cyclosporine. Which assessment finding is most concerning to the nurse?
- AElevated serum creatinine✓ 正解血清肌酸酐升高
- BGingival hyperplasia牙齦增生
- CMild tremor輕微震顫
- DIncreased hair growth毛髮生長增加
— Explanation · 中文詳解 —
Cyclosporine 是一種免疫抑制劑，廣泛用於器官移植。其主要副作用為腎毒性（Nephrotoxicity），表現為肌酸酐上升。其他選項如牙齦增生、多毛或輕微震顫均屬常見但非致命的副作用，腎毒性則直接關係到藥物的長期使用安全性。
Cyclosporine is an immunosuppressant widely used in organ transplantation. Its principal adverse effect is nephrotoxicity, manifested as elevated serum creatinine. Other options, such as gingival hyperplasia, hirsutism, and mild tremor, are common but non-fatal side effects, while nephrotoxicity directly affects the long-term safety of continued therapy.
✦ 台美臨床差異
兩地移植中心皆要求極嚴格的藥物濃度監測（Trough levels）以預防腎毒性。