一位重度憂鬱症病患服用氟西汀（Fluoxetine）兩週，表示：「我感覺沒什麼差別。」護理師應如何回應？
A client diagnosed with major depressive disorder has been on fluoxetine for 2 weeks. The client states, 'I don't feel any different.' Which response by the nurse is most appropriate?
- AIt can take several weeks for the medication to reach full therapeutic effect✓ 正解藥物可能需要數週才能達到完整的治療效果
- BPerhaps we should discuss switching to a different antidepressant也許我們應該討論更換為其他抗憂鬱藥物
- CThe medication usually works within 48 hours該藥物通常在48小時內生效
- DYou should stop the medication if it is not working如果藥物無效，您應該停止服用
SSRI類藥物如氟西汀，其抗憂鬱效果通常需要 2 到 4 週甚至更久才能顯現。護理師應教育病人關於藥物動力學的預期目標，以提高服藥遵從性。擅自停藥（選項D）或過早更換（選項B）皆屬錯誤臨床處置，需與醫師討論評估後的反應。
SSRIs such as fluoxetine generally require 2 to 4 weeks or longer to produce a noticeable antidepressant effect. The nurse should educate the client about the expected pharmacokinetic time course in order to improve medication adherence. Stopping the medication on one's own (option D) or switching too early (option B) are both inappropriate clinical actions; any changes must be discussed with and evaluated by the physician.
台美對藥物衛教一致，但美國護理師常參與藥物門診追蹤，台灣則多由醫師評估療效。