— 藥理與非經腸給藥 · EASY · MCQ —
病人服用華法林（Warfarin）治療，護理師應監測哪項實驗室數值以評估藥效？
A client is prescribed warfarin therapy. Which laboratory value should the nurse monitor to evaluate the effectiveness of this medication?
- AActivated Clotting Time (ACT)活化部分凝血活酶時間 (ACT)
- BPartial Thromboplastin Time (PTT)部分凝血活酶時間 (PTT)
- CBleeding Time出血時間
- DInternational Normalized Ratio (INR)✓ 正解國際標準化比值 (INR)
— Explanation · 中文詳解 —
華法林屬於維生素 K 拮抗劑，透過抑制凝血因子合成達到抗凝血效果。INR 是臨床監測華法林療效的標準指標，能跨實驗室標準化凝血時間。PTT 用於監測肝素（Heparin），而 ACT 用於手術期間的高劑量肝素監測。
Warfarin is a vitamin K antagonist that produces anticoagulation by inhibiting the synthesis of clotting factors. The INR is the standard clinical indicator for monitoring warfarin therapy and standardizes prothrombin time across laboratories. PTT is used to monitor heparin, while ACT is used for monitoring high-dose heparin during surgery.
✦ 台美臨床差異
美台臨床對於 Warfarin 的目標 INR 範圍設定標準一致，均參考國際治療指南。