— 藥理與非經腸給藥 · MEDIUM · MCQ —
護理師準備對深部靜脈栓塞病人給予肝素（heparin），應優先檢查哪項檢驗值？
A nurse is preparing to administer heparin to a client with a deep vein thrombosis. Which laboratory value should the nurse prioritize checking?
- AProthrombin time (PT)凝血酶原時間 (PT)
- BInternational Normalized Ratio (INR)國際標準化比率 (INR)
- CPlatelet count血小板計數
- DActivated partial thromboplastin time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
— Explanation · 中文詳解 —
肝素（Heparin）透過抑制凝血因子來達成抗凝血效果，其監測指標為 aPTT。PT 與 INR 是監測華法林（Warfarin）的指標。血小板計數雖需監測以防肝素引發的血小板低下症，但評估治療效果的黃金指標為 aPTT。
Heparin produces its anticoagulant effect by inhibiting clotting factors, and its monitoring parameter is aPTT. PT and INR are monitoring parameters for warfarin. Platelet count must be monitored to detect heparin-induced thrombocytopenia, but the gold standard for evaluating therapeutic effect is aPTT.
✦ 台美臨床差異
台灣目前更多採用 Anti-Xa 活動度來監測肝素，aPTT 仍廣泛應用，但部分醫學中心已轉型。