— 藥理與非經腸給藥 · HARD · SATA —
對於患有阿斯匹靈加重呼吸道疾病（AERD）的病人，護理師應避免給予哪些藥物？（選所有適合的）
Which medications should the nurse avoid administering to a client with aspirin-exacerbated respiratory disease (AERD)? (Select all that apply.)
- AIbuprofen✓ 正解布洛芬
- BNaproxen✓ 正解萘普生
- CAcetaminophen乙醯胺酚
- DCelecoxib塞來昔布
- EKetorolac✓ 正解酮咯酸
— Explanation · 中文詳解 —
AERD 病人對 COX-1 抑制劑有交叉反應。非類固醇抗發炎藥（NSAIDs）如 Ibuprofen, Naproxen 和 Ketorolac 會抑制 COX-1，引發嚴重的氣管收縮。Acetaminophen 在低劑量下通常安全，Celecoxib 為選擇性 COX-2 抑制劑，通常亦可安全使用。
Clients with AERD exhibit cross-reactivity with COX-1 inhibitors. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, and ketorolac inhibit COX-1 and can trigger severe bronchoconstriction. Acetaminophen is generally safe at low doses, and celecoxib, a selective COX-2 inhibitor, can also typically be used safely.
✦ 台美臨床差異
AERD 診斷在台灣臨床較少被系統性歸類，護理衛教時常需特別提醒病人避開所有市售止痛藥中的 NSAIDs 成份。