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藥理與非經腸給藥 · MEDIUM · SATA

病人正在使用地高辛(Digoxin)。下列哪些跡象暗示地高辛中毒?(選所有適合的)

A nurse is caring for a client receiving digoxin. Which findings suggest digoxin toxicity? (Select all that apply.)

  • AYellow-green halos around lights✓ 正解
    燈光周圍出現黃綠色光暈
  • BBradycardia✓ 正解
    心搏過緩
  • CNausea and vomiting✓ 正解
    噁心和嘔吐
  • DTachycardia
    心搏過速
  • EIncreased appetite
    食慾增加
Explanation · 中文詳解

地高辛(Digoxin)具有狹窄的治療指數,中毒通常發生於血清濃度超過 2.0 ng/mL 時。中毒表現反映了藥物對心臟傳導系統、中樞神經及消化系統的影響。臨床上,護理師需警惕這些中毒徵兆,特別是在病人合併低鉀血症(Hypokalemia)時,因為低鉀會增加地高辛與心肌受體的結合力,進而加劇毒性反應。

Digoxin has a narrow therapeutic index, and toxicity typically occurs when serum levels exceed 2.0 ng/mL. Toxic manifestations reflect the drug's effects on the cardiac conduction system, central nervous system, and gastrointestinal system. Clinically, the nurse must remain vigilant for these signs of toxicity, particularly when the patient has concurrent hypokalemia, because low potassium increases digoxin's binding to myocardial receptors and thereby intensifies the toxic response.

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