— 生理適應 · MEDIUM · MCQ —
一位心房顫動病人被處方warfarin。哪項發現提示藥物有效？
A client with atrial fibrillation is prescribed warfarin. Which finding suggests the medication is therapeutic?
- APlatelet count of 150,000/mm³血小板計數 150,000/mm³
- BInternational Normalized Ratio (INR) of 3.0✓ 正解國際標準化比值 (INR) 為 3.0
- CActivated partial thromboplastin time (aPTT) of 45 seconds活化部分凝血活酶時間 (aPTT) 為 45 秒
- DInternational Normalized Ratio (INR) of 1.2國際標準化比值 (INR) 為 1.2
— Explanation · 中文詳解 —
warfarin 的治療目標是使 INR 維持在 2.0-3.0 之間，以有效預防血栓形成。INR 3.0 落在此治療範圍內。INR 1.2 表示抗凝血作用不足；aPTT 主要監測肝素，非 warfarin；血小板計數正常。
An International Normalized Ratio (INR) of 3.0 indicates that warfarin therapy is therapeutic for a client with atrial fibrillation, as the target range is typically 2.0 to 3.0. This level suggests adequate anticoagulation to prevent clot formation without being excessively high.
✦ 台美臨床差異
美國醫師會根據病人風險評估決定 INR 目標值；台灣則依循國際指引，但病人對藥物交互作用和出血風險的認知差異大，需加強衛教。