— 藥理與非經腸給藥 · MEDIUM · MCQ —
病人服用華法林（Warfarin），關於飲食與藥物交互作用，下列哪項指導最為關鍵？
A client is prescribed Warfarin. Which teaching point is essential regarding diet and medication interaction?
- ATake the medication with high-protein meals隨高蛋白餐點服藥
- BMaintain consistent intake of Vitamin K✓ 正解維持維生素K攝取量一致
- CAvoid all green leafy vegetables避免所有綠葉蔬菜
- DIncrease intake of grapefruit juice增加葡萄柚汁攝取
— Explanation · 中文詳解 —
Warfarin 的作用機轉是透過抑制肝臟中維生素 K 依賴性凝血因子的合成來達到抗凝血效果。病人的飲食中維生素 K 的攝取量若出現大幅波動，會直接影響 INR（國際標準化比率）值，導致治療失效或出血風險增加。指導重點不在於「禁止」食用綠色蔬菜，而是要求病人維持「穩定」的攝取習慣，讓醫師能依此基準調整劑量。
Warfarin works by inhibiting vitamin K-dependent clotting factors, so fluctuations in dietary vitamin K intake can cause unpredictable changes in the INR and affect anticoagulation efficacy. Patients should be instructed to maintain a consistent intake of vitamin K-rich foods rather than avoiding them entirely, allowing for stable dosing and effective therapy management.