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藥理與非經腸給藥 · EASY · MCQ

護理師準備給予病人華法林(Warfarin)。給藥前應確認哪項檢驗數據?

A nurse is preparing to administer warfarin to a client. Which laboratory result should the nurse verify before medication administration?

  • AaPTT
    活化部分凝血活酶時間 (aPTT)
  • BPlatelet count
    血小板計數
  • CPT/INR✓ 正解
    凝血酶原時間/國際標準比值 (PT/INR)
  • DHgb/Hct
    血紅素/血球容積比 (Hgb/Hct)
Explanation · 中文詳解

華法林(Warfarin)屬於維生素 K 拮抗劑,透過抑制肝臟中維生素 K 依賴性凝血因子(II, VII, IX, X)的合成來發揮抗凝血作用。由於該藥物治療指數狹窄且易受飲食、藥物交互作用影響,必須定期監測凝血功能。PT/INR 是評估華法林療效的黃金標準,INR 數值能將不同實驗室的 PT 結果標準化,確保抗凝血效果維持在治療區間(通常為 2.0-3.0,視適應症而定),以平衡栓塞預防與出血風險。給藥前核對最新數據是護理師執行給藥安全(Medication Safety)的關鍵步驟。

Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors, so its efficacy must be monitored using the Prothrombin Time (PT) and International Normalized Ratio (INR). The nurse must verify these results to ensure the client's coagulation status is within the therapeutic range before administration. aPTT is used for heparin, not warfarin.

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