— 藥理與非經腸給藥 · EASY · MCQ —
病人因深層靜脈栓塞(DVT)被處方肝素(Heparin)治療。哪項檢查用於監測肝素的療效?
A client is prescribed heparin therapy for a DVT. Which laboratory test is used to monitor the effectiveness of heparin?
- AHematocrit血球容積比
- BPT凝血酶原時間
- CINR國際標準化比值
- DaPTT✓ 正解活化部分凝血活酶時間
— Explanation · 中文詳解 —
肝素(Heparin)是一種抗凝血藥物,主要透過活化抗凝血酶 III(Antithrombin III)來抑制凝血酶與其他凝血因子的活性。臨床上,為了監測肝素的抗凝血效果並調整劑量,標準檢驗為活化部分凝血活酶時間(aPTT)。護理師需根據 aPTT 的結果,對照醫院的治療區間(Therapeutic range)來調整輸注速率,以預防出血或栓塞惡化。
The activated partial thromboplastin time (aPTT) is the standard laboratory test used to monitor the therapeutic effectiveness of unfractionated heparin. While PT and INR are used to monitor warfarin therapy, aPTT reflects the intrinsic coagulation pathway affected by heparin.