— 藥理與非經腸給藥 · MEDIUM · MCQ —
病人因深部靜脈栓塞接受靜脈輸注肝素(Heparin)。護理師應監測哪項檢驗數據以評估治療成效?
A client is prescribed intravenous heparin for deep vein thrombosis. Which laboratory value should the nurse monitor to evaluate the effectiveness of the therapy?
- AActivated partial thromboplastin time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- BInternational Normalized Ratio (INR)國際正常化比值 (INR)
- CProthrombin time (PT)凝血酶原時間 (PT)
- DPlatelet count血小板計數
— Explanation · 中文詳解 —
肝素(Heparin)透過抑制凝血因子來延長凝血時間,臨床上以 aPTT 作為監測指標。PT/INR 用於監測口服抗凝血劑如 Warfarin 的效果。血小板數值雖也需監測(防肝素誘發之血小板低下症 HIT),但評估藥效仍首選 aPTT。
Activated partial thromboplastin time (aPTT) is the standard laboratory test used to monitor the therapeutic effectiveness of intravenous heparin therapy. While platelet counts are monitored for safety regarding heparin-induced thrombocytopenia, aPTT specifically evaluates the anticoagulant effect.
✦ 台美臨床差異
台美對於肝素監測均一致使用 aPTT,但台灣臨床常使用 anti-Xa 來監測低分子量肝素(LMWH)。