— 藥理與非經腸給藥 · HARD · SATA —
下列哪些藥物需要監測無顆粒球症(agranulocytosis)？（選所有適合的）
Which of the following medications require monitoring for agranulocytosis? (Select all that apply.)
- AClozapine✓ 正解氯氮平
- BPropylthiouracil (PTU)✓ 正解丙硫氧嘧啶 (PTU)
- CMethimazole✓ 正解甲巯咪唑
- DAspirin阿斯匹靈
- ELithium鋰鹽
— Explanation · 中文詳解 —
Clozapine、PTU 及 Methimazole 均有導致無顆粒球症的潛在風險。此為致命性白血球急遽下降，用藥期間需定期監測血球計數(CBC)，若病人出現發燒、喉嚨痛等感染徵象應立即停藥並就醫。
Clozapine, PTU, and Methimazole all carry a potential risk of inducing agranulocytosis. This is a life-threatening, sudden drop in white blood cells, so during use, periodic monitoring of CBC is required; if the patient develops fever, sore throat, or other signs of infection, the drug must be stopped immediately and medical evaluation sought.
✦ 台美臨床差異
台灣針對 Clozapine 使用有嚴格的登錄與血球監測系統，確保病人安全。