— 藥理與非經腸給藥 · EASY · MCQ —
病人因深層靜脈栓塞接受肝素點滴治療。護理師應監測哪項檢驗值以評估治療成效？
A client is prescribed intravenous heparin therapy for deep vein thrombosis. Which laboratory value should the nurse monitor to evaluate the effectiveness of the heparin infusion?
- AProthrombin Time (PT)凝血酶原時間 (PT)
- BActivated Partial Thromboplastin Time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- CPlatelet count血小板計數
- DInternational Normalized Ratio (INR)國際標準化比值 (INR)
— Explanation · 中文詳解 —
肝素（Heparin）透過抑制凝血因子的作用影響內源性凝血路徑，臨床上以 aPTT 作為監測其抗凝血強度的標準指標。目標值通常設定在正常值的 1.5 至 2.5 倍。INR 與 PT 用於監測華法林（Warfarin）的效果，與肝素無關。
Heparin affects the intrinsic coagulation pathway by inhibiting clotting factors, and aPTT is the standard indicator for monitoring its anticoagulant intensity clinically. The therapeutic target is usually 1.5 to 2.5 times the normal value. INR and PT are used to monitor warfarin therapy and are unrelated to heparin.
✦ 台美臨床差異
美國常使用 anti-Xa 監測肝素，但 aPTT 仍為常見標準；台灣醫療體系多數仍高度依賴 aPTT。