一位深部靜脈栓塞病人正在接受肝素（Heparin）持續靜脈滴注，護理師應監測哪項檢驗數值以評估治療效果？
A client is receiving a continuous heparin infusion for deep vein thrombosis. Which laboratory value should the nurse monitor to evaluate the effectiveness of this therapy?
- AActivated partial thromboplastin time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- BProthrombin time (PT)凝血酶原時間 (PT)
- CInternational Normalized Ratio (INR)國際標準化比率 (INR)
- DPlatelet count血小板計數
肝素主要作用於內源性凝血路徑，其抗凝血療效需透過 aPTT 數值進行監測與滴定。治療目標通常為控制在正常值的 1.5 到 2.5 倍之間。PT 與 INR 則是監測口服抗凝血劑（如 Warfarin）的指標，而血小板計數主要是監測肝素誘導之血小板減少症（HIT）風險，而非藥物效能。
Heparin acts primarily on the intrinsic coagulation pathway, and its anticoagulant effect is monitored and titrated using the aPTT. The therapeutic target is generally 1.5 to 2.5 times the control value. PT and INR are used to monitor oral anticoagulants such as warfarin, while platelet count is monitored mainly to detect heparin-induced thrombocytopenia (HIT) rather than to assess drug efficacy.
台美兩地皆依據 aPTT 數值配合醫院制訂的肝素滴定流程（Heparin Protocol）執行給藥。