— 藥理與非經腸給藥 · MEDIUM · MCQ —
護理師照護肝素輸注(Heparin drip)的病人。哪項實驗室檢測可測量藥物療效?
A nurse is caring for a patient on heparin drip. Which laboratory test measures therapeutic effectiveness?
- AINRINR
- BPTPT
- CBleeding time出血時間
- DPTT✓ 正解PTT
— Explanation · 中文詳解 —
肝素(Heparin)的作用機轉是透過活化抗凝血酶 III 來抑制凝血因子,臨床上使用部分凝血活酶時間(aPTT 或 PTT)來監測其療效。PT 與 INR 是用來監測華法林(Warfarin)的。因此,D 選項是正確指標。
Heparin acts by activating antithrombin III to inhibit clotting factors; the activated partial thromboplastin time (aPTT or PTT) is used clinically to monitor its therapeutic effect. PT and INR are used to monitor warfarin. Therefore, option D is the correct indicator.
✦ 台美臨床差異
兩地均採 aPTT 監測,但在劑量調整上,美國多由電腦系統與藥師計算調整,台灣則多由醫師依數據開立醫囑。