— 藥理與非經腸給藥 · HARD · SATA —
下列哪些藥物具有潛在的耳毒性(Ototoxicity)?(選所有適合的)
Which of the following medications are known for potential ototoxicity? (Select all that apply.)
- AGentamicin✓ 正解慶大黴素(Gentamicin)
- BFurosemide✓ 正解呋塞米(Furosemide)
- CVancomycin✓ 正解萬古黴素(Vancomycin)
- DAspirin✓ 正解阿斯匹靈(Aspirin)
- EAtorvastatin阿托伐他汀(Atorvastatin)
— Explanation · 中文詳解 —
耳毒性是多種藥物的嚴重副作用,包括胺基糖苷類抗生素(Gentamicin)、Loop 利尿劑(Furosemide)、萬古黴素(Vancomycin)以及高劑量阿斯匹靈(Aspirin)。Atorvastatin(史他汀類)主要風險為肌肉病變,非耳毒性。
Gentamicin, furosemide, vancomycin, and high-dose aspirin are all associated with ototoxicity, which may present as tinnitus or hearing loss. Aminoglycosides and loop diuretics are classic causes, while vancomycin can lead to permanent damage. Atorvastatin is associated with myopathy, not ototoxicity.
✦ 台美臨床差異
兩地臨床皆嚴格監測這些藥物的劑量與頻率,美國藥師常會介入審核劑量以避免這些併發症。