— 藥理與非經腸給藥 · MEDIUM · MCQ —
病人診斷為甲狀腺機能亢進並處方 propylthiouracil (PTU)。護理師應監測哪項指標以評估藥效？
A client is diagnosed with hyperthyroidism and is prescribed propylthiouracil (PTU). Which outcome should the nurse monitor to evaluate drug effectiveness?
- ADecreased serum T3 and T4✓ 正解血清 T3 和 T4 降低
- BDecreased heart rate心率降低
- CIncreased serum TSH血清 TSH 升高
- DIncreased appetite食慾增加
— Explanation · 中文詳解 —
Propylthiouracil (PTU) 是抗甲狀腺藥物，其作用機轉是抑制甲狀腺過氧化酶（Thyroid peroxidase），從而減少甲狀腺素（T3/T4）的合成。評估其療效，應直接監測甲狀腺素數值是否趨於正常。臨床上，隨著 T3/T4 下降，病人的代謝率會隨之改善，心跳與體重也會恢復正常。
Propylthiouracil (PTU) is an antithyroid agent whose mechanism is the inhibition of thyroid peroxidase, thereby reducing the synthesis of thyroid hormones (T3/T4). To evaluate its efficacy, the nurse should monitor whether thyroid hormone levels return to normal. Clinically, as T3/T4 decrease, the client's metabolic rate improves and heart rate and weight return to normal.