— 藥理與非經腸給藥 · MEDIUM · MCQ —
病患因深層靜脈栓塞處方靜脈肝素治療。護理師應監測哪項檢驗值以評估治療效果？
A client is prescribed intravenous heparin therapy for deep vein thrombosis. Which laboratory value should the nurse monitor to evaluate the effectiveness of the treatment?
- AProthrombin Time (PT)凝血酶原時間（PT）
- BBleeding time出血時間
- CInternational Normalized Ratio (INR)國際標準化比值（INR）
- DActivated Partial Thromboplastin Time (aPTT)✓ 正解活化部分凝血活酶時間（aPTT）
— Explanation · 中文詳解 —
肝素（Heparin）是一種抗凝血藥物，主要作用於內源性凝血路徑，透過強化抗凝血酶 III（Antithrombin III）來抑制凝血因子。臨床上評估其抗凝血效果的黃金標準檢驗值是「活化部分凝血活酶時間」（aPTT）。PT 與 INR 則是用來監測 Warfarin 的指標，兩者機轉不同，臨床使用時務必區分清楚，避免混淆。
Intravenous heparin affects the intrinsic coagulation pathway, so its therapeutic effectiveness is monitored using the activated partial thromboplastin time (aPTT). Unlike warfarin, which is monitored via PT and INR, heparin therapy requires aPTT measurements to ensure the dosage is within the safe and effective range.