— 藥理與非經腸給藥 · EASY · MCQ —
護理師正在為病人給予 warfarin。護理師應監測哪項實驗室數據以確定該藥物的治療效果？
A nurse is administering a dose of warfarin to a client. Which laboratory value should the nurse monitor to determine the therapeutic effectiveness of this medication?
- AProthrombin time (PT)凝血酶原時間 (PT)
- BPartial thromboplastin time (PTT)部分凝血活酶時間 (PTT)
- CPlatelet count血小板計數
- DInternational normalized ratio (INR)✓ 正解國際標準化比值 (INR)
— Explanation · 中文詳解 —
Warfarin 的作用機轉是抑制肝臟合成維生素 K 依賴性凝血因子（II, VII, IX, X）。臨床上，INR（International Normalized Ratio）是標準化的凝血評估指標，相較於 PT，INR 能在不同實驗室間提供一致的治療療效判斷，是監測 Warfarin 的黃金標準。
Warfarin acts by inhibiting hepatic synthesis of vitamin K-dependent clotting factors (II, VII, IX, X). Clinically, the International Normalized Ratio (INR) is the standardized coagulation assessment tool; compared with PT, INR provides consistent therapeutic interpretation across different laboratories and is the gold standard for monitoring warfarin therapy.