— 藥理與非經腸給藥 · HARD · SATA —
使用慶大黴素（Gentamicin）的病人，下列哪些評估發現需警惕藥物毒性？（選所有適合的）
Which assessment findings should alert the nurse to potential toxicity in a client receiving Gentamicin? (Select all that apply.)
- ATinnitus or hearing loss✓ 正解耳鳴或聽力喪失
- BIncreased serum creatinine✓ 正解血清肌酸酐增加
- CPeripheral paresthesia周邊感覺異常
- DPresence of protein in urine✓ 正解尿液中存在蛋白質
- EAtaxia or vertigo✓ 正解步態不穩或眩暈
— Explanation · 中文詳解 —
慶大黴素為胺基醣苷類（Aminoglycosides），主要毒性為耳毒性（第八對腦神經受損）與腎毒性。耳毒性表現為耳鳴、聽力受損、暈眩及步態不穩；腎毒性則見於肌酸酐上升、尿蛋白增加。周邊感覺異常非其主要毒性。
Gentamicin is an aminoglycoside; its main toxicities are ototoxicity (damage to cranial nerve VIII) and nephrotoxicity. Ototoxicity manifests as tinnitus, hearing loss, vertigo, and unsteady gait; nephrotoxicity manifests as a rising serum creatinine and increased urinary protein. Peripheral paresthesia is not a primary toxicity of this drug.
✦ 台美臨床差異
台灣醫院通常會執行嚴格的血中濃度監測（Trough level），護理師需精確計時採血。