— 藥理與非經腸給藥 · HARD · SATA —
下列哪些藥物在對磺胺類(sulfa)過敏的病人中是禁忌的?(選所有適合的)
Which of the following medications are contraindicated in clients with a sulfa allergy? (Select all that apply.)
- ATrimethoprim-Sulfamethoxazole✓ 正解Trimethoprim-Sulfamethoxazole(複方磺胺甲惡唑)
- BHydrochlorothiazide✓ 正解Hydrochlorothiazide(氫氯噻嗪)
- CCelecoxib✓ 正解Celecoxib(塞來昔布)
- DFurosemide✓ 正解Furosemide(呋塞米)
- EAcetaminophenAcetaminophen(乙醯胺酚)
— Explanation · 中文詳解 —
磺胺過敏的交叉反應常發生在同樣具有磺胺基團的藥物上,包括 Trimethoprim-Sulfamethoxazole(抗生素)、Thiazide 利尿劑(如 HCTZ)、Loop 利尿劑(如 Furosemide)以及部分 COX-2 抑制劑(如 Celecoxib)。Acetaminophen 結構完全不同,無此顧慮。
Cross-reactivity in sulfa allergy commonly occurs with other medications that also contain a sulfonamide moiety, including trimethoprim-sulfamethoxazole (an antibiotic), thiazide diuretics (such as hydrochlorothiazide), loop diuretics (such as furosemide), and some COX-2 inhibitors (such as celecoxib). Acetaminophen has a completely different structure and poses no such concern.
✦ 台美臨床差異
美國醫院藥局系統常會自動標示過敏警示,台灣護理師則需仰賴藥物過敏紀錄卡。