護理師照護一位有深部靜脈栓塞病史且正在接受肝素點滴的病人。護理師應監測哪項實驗室數值以評估治療效果？
A nurse is caring for a client with a history of deep vein thrombosis who is receiving a heparin infusion. Which laboratory value should the nurse monitor to assess the effectiveness of this therapy?
- AProthrombin Time (PT)凝血酶原時間 (PT)
- BActivated Partial Thromboplastin Time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- CInternational Normalized Ratio (INR)國際標準化比值 (INR)
- DPlatelet count血小板計數
肝素（Heparin）透過抑制凝血酶（Thrombin）及凝血因子 Xa 的活性發揮抗凝血作用，主要監測內因性凝血路徑。活化部分凝血活酶時間（aPTT）是評估肝素治療效果的核心指標，因為它對肝素劑量的變化非常敏感，能確保抗凝效果達到治療目標（通常為正常值的 1.5 至 2.5 倍），同時監測出血風險。
Heparin exerts its anticoagulant effect by inhibiting thrombin and factor Xa within the intrinsic coagulation pathway. The activated partial thromboplastin time (aPTT) is the standard laboratory test used to monitor heparin therapy because it is highly sensitive to changes in heparin dosage. Maintaining the aPTT at 1.5 to 2.5 times the normal value ensures therapeutic efficacy while minimizing bleeding risks.