— 藥理與非經腸給藥 · MEDIUM · MCQ —
護理師照顧一位因深層靜脈栓塞接受肝素點滴的病人，應監測何種檢驗數據以評估藥效？
A nurse is caring for a client receiving a heparin infusion for DVT. Which laboratory value should the nurse monitor to evaluate the effectiveness of this therapy?
- AInternational Normalized Ratio (INR)國際標準化比值 (INR)
- BPlatelet count血小板計數
- CActivated partial thromboplastin time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- DProthrombin time (PT)凝血酶原時間 (PT)
— Explanation · 中文詳解 —
肝素（Heparin）透過影響內因性凝血路徑發揮作用，臨床上以 aPTT 來監測其抗凝血效果。PT 和 INR 是用來監測 warfarin 的療效，血小板則是監測肝素引發血小板低下症（HIT）之副作用，而非藥效。
Activated partial thromboplastin time (aPTT) is the standard laboratory test used to monitor the therapeutic effectiveness of unfractionated heparin, as it reflects the intrinsic coagulation pathway. In contrast, prothrombin time (PT) and INR are used to monitor warfarin therapy, while platelet counts are monitored for safety regarding heparin-induced thrombocytopenia rather than efficacy.
✦ 台美臨床差異
台美臨床對於肝素調整皆依據醫院設立之 aPTT 抗凝血處方集（Nomogram）。