— 藥理與非經腸給藥 · EASY · MCQ —
一位慢性腎臟病病人被開立處方紅血球生成素（Epoetin alfa）。哪項檢驗結果顯示藥物有效？
A client with chronic kidney disease is prescribed epoetin alfa. Which laboratory result indicates that the medication is effective?
- ADecrease in serum potassium血清鉀降低
- BIncrease in white blood cell count白血球計數增加
- CIncrease in hemoglobin level✓ 正解血紅素水平增加
- DDecrease in blood urea nitrogen血液尿素氮降低
— Explanation · 中文詳解 —
紅血球生成素（Epoetin alfa）的主要藥理機轉是模擬體內紅血球生成素，刺激骨髓中的紅血球前驅細胞分化。對於慢性腎臟病（CKD）病人，由於腎臟分泌紅血球生成素能力下降，常伴隨腎性貧血。治療成功的臨床指標就是血紅素（Hemoglobin）與血容積（Hematocrit）數值的回升，這能改善氧氣攜帶能力與貧血症狀。
Epoetin alfa is a synthetic form of erythropoietin that stimulates red blood cell production in the bone marrow, making it the treatment of choice for anemia associated with chronic kidney disease. An increase in hemoglobin levels indicates that the medication is effectively promoting erythropoiesis and improving the client's oxygen-carrying capacity.