— 藥理與非經腸給藥 · MEDIUM · SATA —
護理師對於處方阿侖膦酸鈉（Alendronate）的骨質疏鬆症病人應提供哪些指導？（選所有適合的）
Which of the following instructions should the nurse provide to a client prescribed alendronate for osteoporosis? (Select all that apply.)
- ATake the medication with a full glass of water✓ 正解以一杯滿的水送服藥物
- BRemain upright for at least 30 minutes after ingestion✓ 正解服用後至少保持直立姿勢 30 分鐘
- CTake the medication with breakfast for better absorption與早餐一起服用藥物以促進吸收
- DAvoid all other medications for 30 minutes✓ 正解避免在 30 分鐘內服用其他藥物
- EReport any difficulty swallowing or chest pain immediately✓ 正解立即報告任何吞嚥困難或胸痛
— Explanation · 中文詳解 —
雙膦酸鹽類藥物（如 Alendronate）具有強烈食道刺激性。病人必須空腹服用，搭配一大杯水，且服藥後至少 30 分鐘內保持直立位，以防止藥物逆流造成食道潰瘍。若出現吞嚥困難或胸痛，需立即回報，這可能是食道炎徵兆。
Alendronate can cause severe esophageal irritation, so it must be taken with a full glass of water on an empty stomach. The client should remain upright for at least 30 minutes after ingestion and avoid other medications during this time to ensure proper absorption and prevent reflux.
✦ 台美臨床差異
台灣門診衛教常強調此藥對食道的刺激性，醫護對服藥姿勢的指導與美國一致。