— 藥理與非經腸給藥 · HARD · MCQ —
病人患有甲狀腺功能亢進並接受 Propylthiouracil (PTU) 治療。護理師應監測該藥物的哪項嚴重副作用？
A client is diagnosed with hyperthyroidism and is being treated with Propylthiouracil (PTU). The nurse should monitor the client for which serious adverse effect?
- AConstipation便秘
- BBradycardia心搏過慢
- CHyperglycemia高血糖
- DAgranulocytosis✓ 正解粒細胞缺乏症
— Explanation · 中文詳解 —
PTU 的嚴重副作用為顆粒性白血球缺乏症（Agranulocytosis）。病人在用藥期間若出現發燒、喉嚨痛等感染徵兆，應立即回診進行 CBC 檢查。其餘選項中，PTU 反而可能導致心跳過快減緩或代謝變化，但白血球低下是具致命性的免疫抑制反應。
Propylthiouracil (PTU) can cause agranulocytosis, a rare but life-threatening drop in white blood cells that increases infection risk. Clients should be monitored for signs of infection such as fever or sore throat, which require immediate medical evaluation.
✦ 台美臨床差異
台美臨床對於服用抗甲狀腺藥物病人的感染監測指導原則一致，皆強調發燒需告知的重要性。