一位病人正接受肝素（Heparin）靜脈點滴注射。護理師應監測哪項實驗室數值以評估治療效果？
A client is receiving an intravenous infusion of heparin. Which laboratory value should the nurse monitor to evaluate the effectiveness of the therapy?
- AProthrombin time (PT)凝血酶原時間 (PT)
- BPlatelet count血小板計數
- CInternational Normalized Ratio (INR)國際標準化比值 (INR)
- DActivated partial thromboplastin time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
靜脈注射普通肝素（Unfractionated Heparin）的治療效果是透過監測活化部分凝血活酶時間（aPTT）來評估的。治療目標通常是正常基準值的 1.5 到 2.5 倍。PT 和 INR 則是用於監測口服抗凝血劑 Warfarin 的指標。雖然 Platelet count（血小板計數）也需要監測以排除肝素誘發的血小板低下症（HIT），但它不是評估藥效的主要指標。
Activated partial thromboplastin time (aPTT) is the standard laboratory test used to monitor the therapeutic effectiveness of intravenous unfractionated heparin, with a target range typically 1.5 to 2.5 times the normal control value. While platelet counts are monitored to detect heparin-induced thrombocytopenia, they do not measure anticoagulation efficacy. Prothrombin time (PT) and International Normalized Ratio (INR) are used to monitor oral anticoagulants like warfarin.
台美在 aPTT 監測上一致，但美國醫院常有專門的 Heparin Protocol 由護理師依數值自行調整流速。