— 藥理與非經腸給藥 · HARD · MCQ —
一位思覺失調症病人使用 Clozapine。下列哪項副作用被視為危及生命的急症？
A client with schizophrenia is prescribed Clozapine. Which side effect is considered a life-threatening emergency?
- AWeight gain體重增加
- BAgranulocytosis✓ 正解白血球缺乏症
- CHyper-salivation唾液分泌過多
- DDrowsiness嗜睡
— Explanation · 中文詳解 —
Clozapine 最嚴重的致命副作用是顆粒性白血球缺乏症（Agranulocytosis）。此反應會使病人極易遭受嚴重感染，若未及時發現並停藥，死亡率極高。因此，臨床常規要求定期檢測 CBC，監控白血球與中性粒細胞數量。
Regular aerobic exercise increases high-density lipoprotein (HDL) cholesterol, which helps remove low-density lipoprotein (LDL) from arterial walls and reduces the risk of atherosclerosis. This improvement in lipid profile is a primary cardiovascular benefit, whereas exercise typically enhances lung capacity and basal metabolic rate rather than decreasing them.
✦ 台美臨床差異
台美對 Clozapine 的監控嚴格度相當，均有強制性的血液常規檢查門檻，以保障病人用藥安全。