病人獲開立 Alendronate。護理師在出院指導中應包含下列哪項建議？
A client is prescribed Alendronate. Which instruction should the nurse include in the discharge teaching?
- ATake the medication with a meal to prevent stomach upset隨餐服用藥物以預防胃部不適
- BCrush the tablet if you have difficulty swallowing若吞嚥困難，將藥片壓碎
- CSit upright for at least 30 minutes after taking the medication✓ 正解服用藥物後至少保持坐姿 30 分鐘
- DLie down immediately after taking the medication服用藥物後立即躺下
Alendronate 屬於雙磷酸鹽（Bisphosphonates），主要用於治療骨質疏鬆。此類藥物對食道黏膜有強烈的腐蝕性與刺激性，若服藥後立即躺下，藥物容易滯留於食道造成潰瘍、糜爛甚至穿孔。護理指導重點在於確保藥物順利進入胃部，並減少食道接觸時間。病人必須在空腹狀態下以一大杯白開水服用，且服藥後必須保持直立姿勢（坐著或站著）至少 30 分鐘，期間不可進食或服用其他藥物。
Alendronate is a bisphosphonate used mainly for osteoporosis. It is highly corrosive and irritating to the esophageal mucosa; lying down after dosing can trap the drug in the esophagus and cause ulceration, erosion, or even perforation. Teaching emphasizes ensuring the tablet reaches the stomach and minimizing esophageal contact: the client must take it on an empty stomach with a full glass of plain water and remain upright (sitting or standing) for at least 30 minutes, without eating or taking other medications during that time.