病人獲開立 Amiodarone。下列哪項監測指標對長期安全至關重要?
A client is prescribed Amiodarone. Which monitoring parameter is critical for long-term safety?
- AUrinalysis尿液分析
- BBlood glucose level血糖
- CSerum sodium level血清鈉濃度
- DPulmonary function tests✓ 正解肺功能檢查
Amiodarone 是一種廣效性抗心律不整藥物(Antiarrhythmic),具有高度親脂性,極易蓄積於肺組織。其最嚴重且致命的長期副作用為藥物誘發性肺毒性(Pulmonary toxicity),可能導致肺纖維化(Pulmonary fibrosis)。臨床照護中,病人需定期進行肺功能測試(PFTs)及胸部 X 光檢查,以早期偵測肺部異常。這屬於藥物安全性監測的核心項目,優先級高於其他選項。
Amiodarone is a broad-spectrum antiarrhythmic agent with highly lipophilic properties that readily accumulate in pulmonary tissue. Its most severe and potentially fatal long-term adverse effect is drug-induced pulmonary toxicity, which can lead to pulmonary fibrosis. In clinical care, the client must undergo periodic pulmonary function tests (PFTs) and chest radiographs to detect pulmonary abnormalities early. This represents a core aspect of medication safety monitoring and takes priority over the other options.
在美國臨床執業中,針對長期服用 Amiodarone 的病人,除了每 3-6 個月監測甲狀腺功能 (TSH) 與肝功能 (LFTs) 外,Baseline 與定期的肺功能檢查 (PFTs) 是標準作業程序 (Protocol),護理師需主動追蹤並提醒醫師。