— 藥理與非經腸給藥 · MEDIUM · MCQ —
哪種藥物禁用於有嚴重氣喘病史的病人?
Which medication is contraindicated in a client with a history of severe asthma?
- ALisinoprilLisinopril(賴諾普利)
- BPropranolol✓ 正解Propranolol(普萘洛爾)
- CFurosemideFurosemide(呋塞米)
- DAmlodipineAmlodipine(氨氯地平)
— Explanation · 中文詳解 —
Propranolol 是一種非選擇性 beta-受體阻斷劑,會阻斷 beta-2 受體,導致支氣管平滑肌收縮,加重氣喘症狀。其他藥物(如 ACEI、鈣離子通道阻斷劑、利尿劑)與氣喘病灶機轉無直接衝突,相對安全。
Propranolol is a non-selective beta-blocker that blocks beta-2 receptors, leading to bronchial smooth muscle constriction and worsening of asthma symptoms. Other medications (such as ACE inhibitors, calcium channel blockers, and diuretics) have no direct conflict with the pathophysiology of asthma and are relatively safe.
✦ 台美臨床差異
台灣醫師在使用此類藥物前會更謹慎評估,美國亦然,但醫療指引對於選擇性 beta-blocker 的使用會更細緻。