— 藥理與非經腸給藥 · EASY · MCQ —
使用 Famotidine 這類 H2 受體拮抗劑的治療目標是什麼？
What is the therapeutic goal of using an H2 receptor antagonist like Famotidine?
- ANeutralize existing stomach acid中和現有的胃酸
- BIncrease stomach motility增加胃腸蠕動
- CReduce gastric acid secretion✓ 正解減少胃酸分泌
- DCoat the gastric ulcer覆蓋胃潰瘍部位
— Explanation · 中文詳解 —
Famotidine 屬於 H2 受體拮抗劑（H2-receptor antagonist），其作用機轉是競爭性阻斷胃壁細胞上的 H2 受體，從而抑制胃酸的分泌，特別是基礎胃酸與夜間胃酸分泌。這類藥物主要用於胃食道逆流（GERD）、胃潰瘍或十二指腸潰瘍的治療，目的是減少胃內環境的酸度，促進黏膜癒合並緩解症狀。
Famotidine is an H2 receptor antagonist that works by competitively blocking histamine receptors on gastric parietal cells, thereby reducing basal and nocturnal gastric acid secretion. This mechanism helps decrease the acidity of the gastric environment, promoting mucosal healing and symptom relief in conditions such as GERD and peptic ulcers. Unlike antacids, which neutralize existing acid, H2 blockers prevent acid production.