— 藥理與非經腸給藥 · MEDIUM · MCQ —
第一型糖尿病病人同時使用長效胰島素（Glargine）與速效胰島素（Lispro）。這兩種胰島素的主要差別為何？
A client with type 1 diabetes is receiving insulin glargine and insulin lispro. What is the key difference between these two types of insulin?
- ALispro is a long-acting insulinLispro 是一種長效胰島素
- BLispro should be administered with meals✓ 正解Lispro 應隨餐施用
- CGlargine can be mixed in the same syringe with LisproGlargine 可與 Lispro 混合在同一支針筒中
- DGlargine has a peak effect of 2 hoursGlargine 的高峰效應為 2 小時
— Explanation · 中文詳解 —
胰島素的藥物動力學是糖尿病照護的重點。胰島素 Lispro 為速效胰島素，起效快、作用時間短，旨在處理進餐後的血糖波動，因此必須隨餐（或餐前立即）使用。胰島素 Glargine 則為長效胰島素，無明顯高峰（Peakless），提供全天候的基礎胰島素需求，兩者機制完全不同，且因 pH 值差異不可混和在同一針筒內。
Insulin lispro is a rapid-acting insulin designed to cover mealtime carbohydrate intake and should be administered with meals, whereas insulin glargine is a long-acting, peakless basal insulin. Glargine cannot be mixed with other insulins due to pH incompatibility, and it does not have a peak effect like some intermediate-acting insulins.