— 藥理與非經腸給藥 · EASY · MCQ —
一位病人正接受肝素(Heparin)靜脈輸注,護理師應監測哪項檢驗值以評估治療成效?
A client is prescribed intravenous heparin therapy. Which laboratory value should the nurse monitor to evaluate the effectiveness of this therapy?
- AProthrombin time (PT)凝血酶原時間 (PT)
- BActivated partial thromboplastin time (aPTT)✓ 正解活化部分凝血活酶時間 (aPTT)
- CInternational Normalized Ratio (INR)國際標準化比值 (INR)
- DPlatelet count血小板計數
— Explanation · 中文詳解 —
肝素(Heparin)透過抑制凝血因子來延長凝血時間,臨床上使用 aPTT 監測其抗凝血效果。INR 與 PT 主要用於監測口服抗凝血劑(如 Warfarin)。血小板計數雖需定期監測以預防肝素引起的血小板低下症(HIT),但評估藥物「成效」的首選指標仍為 aPTT。
Activated partial thromboplastin time (aPTT) is the standard laboratory test used to monitor the therapeutic effectiveness of intravenous heparin therapy. While platelet counts are monitored to detect adverse effects like heparin-induced thrombocytopenia, aPTT specifically evaluates the drug's anticoagulant efficacy.
✦ 台美臨床差異
台美均使用 aPTT 作為監測指標,但目前臨床亦廣泛使用 anti-Xa 因子測試,其敏感度更高,部分醫學中心已逐漸取代 aPTT。